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Drug Discontinuation Abrupt discontinuation after high-dose or long-term therapy should be avoided Drug-induced adrenocortical insufficiency may persist for months after drug discontinuation Recommendations To reduce the effect of drug-induced adrenocortical insufficiency, gradual dose reduction is recommended In situation of stress, this drug may need to be restarted or doses increased during dose reduction or for up to 12 months after discontinuation to account testosterone steroid injection cycle for drug-induced adrenocortical insufficiency. 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